| Identification | Back Directory | [Name]
PSB-12379 | [CAS]
1802226-78-3 | [Synonyms]
PSB-12379
Adenosine, N-(phenylmethyl)-, 5'-[hydrogen P-(phosphonomethyl)phosphonate] | [Molecular Formula]
C18H23N5O9P2 | [MDL Number]
MFCD31544493 | [MOL File]
1802226-78-3.mol | [Molecular Weight]
515.35 |
| Chemical Properties | Back Directory | [Boiling point ]
894.2±75.0 °C(Predicted) | [density ]
1.89±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Water: 5 mg/ml, sonicated | [form ]
A solid | [pka]
1.62±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear |
| Hazard Information | Back Directory | [Description]
PSB-12379 is an inhibitor of ecto-5’-nucleotidase (CD73; Kis = 2.21 and 9.03 nM for the recombinant human and rat enzyme, respectively). It is selective for CD73 over human nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), -2, and -3, ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), -2, and -3 (Kis = >10,000 nM for all), as well as the purinergic P2Y1 and P2Y12 receptors at 10 μM. PSB-12379 inhibits CD73 in isolated human serum with a Ki value of 18.8 nM. | [Uses]
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2]. | [References]
[1] Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63. DOI:10.1021/acs.jmedchem.5b00802
[2] X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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