| Identification | Back Directory | [Name]
4-Quinolinecarbonitrile, 2-[(1S)-1-amino-3-methylbutyl]-6-(4-pyridinyl)- | [CAS]
1802703-21-4 | [Synonyms]
AAK1-IN-2
4-Quinolinecarbonitrile, 2-[(1S)-1-amino-3-methylbutyl]-6-(4-pyridinyl)- | [Molecular Formula]
C20H20N4 | [MOL File]
1802703-21-4.mol | [Molecular Weight]
316.4 |
| Hazard Information | Back Directory | [Uses]
AAK1-IN-2 (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 can be used for the research of neuropathic pain[1]. | [References]
[1] Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155. DOI:10.1021/acs.jmedchem.1c01966 |
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