| Identification | Back Directory | [Name]
Methanone, [(3R)-3-fluoro-1-pyrrolidinyl][6-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-2-quinolinyl]- | [CAS]
1802848-94-7 | [Synonyms]
ABBV-319
[(3R)-3-fluoropyrrolidin-1-yl](6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone
Methanone, [(3R)-3-fluoro-1-pyrrolidinyl][6-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-2-quinolinyl]- | [Molecular Formula]
C20H15F4N3O2 | [MOL File]
1802848-94-7.mol | [Molecular Weight]
405.35 |
| Chemical Properties | Back Directory | [Boiling point ]
545.4±50.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.73±0.50(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1]. | [IC 50]
hNav1.7: 2.8 μM (IC50); hNav1.8: 3.3 μM (IC50) | [References]
[1] Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743. DOI:10.1016/j.bmc.2022.116743 |
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