| Identification | Back Directory | [Name]
PC Alkyne-PEG4-NHS carbonate ester | [CAS]
1802907-98-7 | [Synonyms]
PC Alkyne-PEG4-NHS ester
PC Alkyne-PEG4-NHS carbonate ester
Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-azaeicos-19-yn-1-yl)oxy]phenyl]ethyl ester | [Molecular Formula]
C29H39N3O14 | [MDL Number]
MFCD29052184 | [MOL File]
1802907-98-7.mol | [Molecular Weight]
653.63 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [form ]
Viscous Liquid | [pka]
15.38±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
PC Alkyne-PEG4-NHS carbonate ester is a photocleavable linker with an alkyne and NHS carbonate ester end group. The NHS ester can react with primary amines. The alkyne can participate in copper-catalyzed Click Chemistry reactions with azide moieties. | [Uses]
PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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