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1802978-47-7

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1802978-47-7 Structure

1802978-47-7 Structure
IdentificationBack Directory
[Name]

Methyltetrazine-propylamine HCl salt
[CAS]

1802978-47-7
[Synonyms]

Methyltetrazine-propylamine HCl salt
1-Propanamine, 3-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-
[Molecular Formula]

C12H15N5O
[MDL Number]

MFCD28334554
[MOL File]

1802978-47-7.mol
[Molecular Weight]

245.28
Chemical PropertiesBack Directory
[Boiling point ]

474.6±55.0 °C(Predicted)
[density ]

1.198±0.06 g/cm3(Predicted)
[pka]

9.24±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Methyltetrazine-Propylamine is click chemistry reagent, the amine group can be attached with carboxylic acid containing molecule in the presence of reagnet such as EDC or HATU. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene)
[Uses]

Methyltetrazine-propylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

Alkyl-Chain
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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