| Identification | Back Directory | [Name]
1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester | [CAS]
1802997-81-4 | [Synonyms]
SEC
1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester | [Molecular Formula]
C22H23ClN2O5 | [MDL Number]
MFCD32857143 | [MOL File]
1802997-81-4.mol | [Molecular Weight]
430.88 |
| Chemical Properties | Back Directory | [Boiling point ]
627.7±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Oil | [pka]
13.31±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation[1][2]. | [in vivo]
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model[1].
| Animal Model: | Luciferase-labeled PC-3M-Luc cells (2×106 per 50 μL sterile HBSS?/?) are orthotopically inoculated into the prostates of 8-week-old nude mice[1].
| | Dosage: | 3 mg/kg/day or 18 mg/kg/day. | | Administration: | IP daily for 3 weeks. | | Result: | Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2, APLN and IL6ST in implanted tumors.
Did not affect the body weight of the mice.
|
| [References]
[1] ShuYan Liu, et al. SEC-induced Activation of ANXA7 GTPase Suppresses Prostate Cancer Metastasis. Cancer Lett. 2018 Mar 1;416:11-23. DOI:10.1016/j.canlet.2017.12.008
[2] ShuYan Liu, et al. A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4. Oncotarget. 2016 Mar 29; 7(13): 16282–16296. DOI:10.18632/oncotarget.7646 |
|
| Company Name: |
Cellosaurus STR
|
| Tel: |
13121892008 |
| Website: |
www.cellosaurus.org |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|