| Identification | Back Directory | [Name]
1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine | [CAS]
180300-43-0 | [Synonyms]
ECyd
TAS 106
ETHYNYCYTIDINE
Ethynylcytidine
3'-Ethynylcytidine
3'-C-Ethynylcytidine
3’-β-C-Ethynylcytidine
cytidine, 3'-c-ethynyl-
Ethynylcytidine (TAS-106)
3'-beta-C-Ethynylcytidine
ECYD;TAS-106;3'-C-ETHYNYLCYTIDINE
3’-beta-C-Ethynylcytidine, ECYD, TAS-106
1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine
1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE
4-Amino-1-((2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | [Molecular Formula]
C11H13N3O5 | [MDL Number]
MFCD00942308 | [MOL File]
180300-43-0.mol | [Molecular Weight]
267.24 |
| Chemical Properties | Back Directory | [Melting point ]
233-235 °C | [Boiling point ]
536.4±60.0 °C(Predicted) | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:127.5(Max Conc. mg/mL);477.1(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);18.71(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.42(Max Conc. mM) | [form ]
A solid | [pka]
11.54±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Ethynylcytidine, is a new nucleoside antimetabolite, and an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction | [in vivo]
In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with an tumor growth inhibition rate (IR) on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine (TAS-106) on all three administration schedules. In particular, administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak[1]. | [storage]
Store at -20°C |
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