| Identification | Back Directory | [Name]
CATHEPSIN INHIBITOR III | [CAS]
180313-86-4 | [Synonyms]
Z-FG-NHO-BZPOME
Z-PHE-GLY-NHO-BZ-POME
CATHEPSIN INHIBITOR III
Glycinamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-N-[(4-methoxybenzoyl)oxy]- | [Molecular Formula]
C27H27N3O7 | [MDL Number]
MFCD01323024 | [MOL File]
180313-86-4.mol | [Molecular Weight]
505.52 |
| Chemical Properties | Back Directory | [density ]
1.275±0.06 g/cm3(Predicted) | [storage temp. ]
10-30°C | [solubility ]
ethanol: 1mg/mL
DMSO: 5mg/mL | [form ]
Solid | [pka]
11.07±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain[1]. | [Biological Activity]
Cell permeable: no''Primary Target
cathepsin B''Product does not compete with ATP.''Reversible: no''k2/Ki = 1 x 10⁴ M-¹ sec-¹ | [References]
[1] Rajgopal Yadavalli, et al. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. J Biol Chem. 2004 May 21;279(21):21948-56. DOI:10.1074/jbc.M400793200 |
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