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180313-86-4

180313-86-4 Structure

180313-86-4 Structure
IdentificationBack Directory
[Name]

CATHEPSIN INHIBITOR III
[CAS]

180313-86-4
[Synonyms]

Z-FG-NHO-BZPOME
Z-PHE-GLY-NHO-BZ-POME
CATHEPSIN INHIBITOR III
Glycinamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-N-[(4-methoxybenzoyl)oxy]-
[Molecular Formula]

C27H27N3O7
[MDL Number]

MFCD01323024
[MOL File]

180313-86-4.mol
[Molecular Weight]

505.52
Chemical PropertiesBack Directory
[density ]

1.275±0.06 g/cm3(Predicted)
[storage temp. ]

10-30°C
[solubility ]

ethanol: 1mg/mL
DMSO: 5mg/mL
[form ]

Solid
[pka]

11.07±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain[1].
[Biological Activity]

Cell permeable: no''Primary Target
cathepsin B''Product does not compete with ATP.''Reversible: no''k2/Ki = 1 x 10⁴ M-¹ sec-¹
[References]

[1] Rajgopal Yadavalli, et al. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation. J Biol Chem. 2004 May 21;279(21):21948-56. DOI:10.1074/jbc.M400793200
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