ChemicalBook--->CAS DataBase List--->1805789-54-1

1805789-54-1

Request For Quotation
1805789-54-1 Structure

1805789-54-1 Structure
IdentificationBack Directory
[Name]

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
[CAS]

1805789-54-1
[Synonyms]

1), (3R,4R)-
PPDA-001 HCL SALT
ICEC0942 (CT7001)
CT7001 hydrochloride
ICEC 0942 hydrochloride
Samuraciclib hydrochloride
ICEC0942;ICE C0942;ICE-C0942;CT7001;CT-7001;CT 7001
(3R,4R)-4-(((7-(Benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-olhydrochloride
3-Piperidinol, 4-3-(1-methylethyl)-7-(phenylmethyl)aminopyrazolo1,5-apyrimidin-5-ylaminomethyl-, hydrochloride (1
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
[Molecular Formula]

C22H31ClN6O
[MDL Number]

MFCD31657343
[MOL File]

1805789-54-1.mol
[Molecular Weight]

430.98
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: Soluble
[form ]

A solid
[color ]

White to light yellow
[InChIKey]

YMNPLAHCOLEZJE-ALSDZXMDNA-N
[SMILES]

N(C1=CC(NC[C@H]2CCNC[C@@H]2O)=NC2=C(C(C)C)C=NN12)CC1C=CC=CC=1.Cl |&1:6,11,r|
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

CT7001 Hydrochloride, is a selective CDK7 inhibitor.
[in vivo]

Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
? The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1].

Animal Model:Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1]
Dosage:100 mg/kg
Administration:Oral gavage; daily; for 14 days
Result:At day 14, tumor growth was inhibited by 60%.
[IC 50]

CDK7: 41 nM (IC50); CDK2: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-(1805789-54-1)1HNMR
1805789-54-1 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Website: https://www.targetmol.com/
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: NANJING YINGWEN BIOTECHNOLOGY CO LTD
Tel: +8613382787392 , +8613382787392
Website: www.aeechem.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Jiangsu yize medical technology co. LTD  Gold
Tel: 18962082606
Website: www.chemicalbook.com/ShowSupplierProductsList30602/0_EN.htm
Company Name: Haiji Pharmaceutical Technology (Suzhou) Co., Ltd  Gold
Tel: 18012778619
Website: https://www.chemicalbook.com/ShowSupplierProductsList1396438/0_EN.htm
Company Name: WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.  
Tel: 17702719238 18971495150;
Website: http://www.sun-shinechem.com/
Company Name: Shanghai Topbiochem Technology Co., Ltd  
Tel: 021-58170097 15801866362;
Website: http://www.topbiochem.com
Company Name: Cool Pharm, Ltd  
Tel: 021-60455363 18019463053
Website: www.coolpharm.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: TaiChem Taizhou Limited  
Tel: 052386810091
Website: https://www.chemicalbook.com/supplier/11410902/1.htm
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Website: http://www.shyuanye.com
Tags:1805789-54-1 Related Product Information