| Identification | Back Directory | [Name]
1H-Pyrrole-2,5-dione, 1-(5-hydroxypentyl) | [CAS]
180608-78-0 | [Synonyms]
N-(5-Hydroxypentyl)maleimide
1H-Pyrrole-2,5-dione, 1-(5-hydroxypentyl) | [Molecular Formula]
C9H13NO3 | [MDL Number]
MFCD28397100 | [MOL File]
180608-78-0.mol | [Molecular Weight]
183.2 |
| Chemical Properties | Back Directory | [Boiling point ]
336.2±25.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
15.14±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1]. | [IC 50]
Non-cleavable Linker | [References]
[1] Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358. |
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