| Identification | Back Directory | [Name]
6-(3-Amino-1H-indazol-4-yl)-N-(4-fluoro-3-methylphenyl)-1-naphthamide | [CAS]
1807466-30-3 | [Synonyms]
6-(3-Amino-1H-indazol-4-yl)-N-(4-fluoro-3-methylphenyl)-1-naphthamide | [Molecular Formula]
C25H19FN4O | [MOL File]
1807466-30-3.mol | [Molecular Weight]
410.44 |
| Chemical Properties | Back Directory | [Boiling point ]
611.002±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.386±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.358±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SYHA1813 is a dual inhibitor of CSF1R and VEGFR. SYHA1813 has potent antitumor activity against GBM[1]. | [References]
[1] Yingqiang Liu, et al. Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma. Acta Pharm Sin B. 2023, 13,12. DOI:10.1016/j.apsb.2023.09.009 |
|
|