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1807512-37-3

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1807512-37-3 Structure

1807512-37-3 Structure
IdentificationBack Directory
[Name]

THP-SS-PEG1-Tos
[CAS]

1807512-37-3
[Synonyms]

THP-SS-PEG1-Tos
Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-, 1-(4-methylbenzenesulfonate)
[Molecular Formula]

C16H24O5S3
[MDL Number]

MFCD28950768
[MOL File]

1807512-37-3.mol
[Molecular Weight]

392.55
Chemical PropertiesBack Directory
[Boiling point ]

539.4±50.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
Hazard InformationBack Directory
[Description]

THP-SS-PEG1-Tos is a cleavable linker containing a THP protecting group and a tosyl end group. Tos is a good leaving group by reacting with nucleophiles, The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent.
[Uses]

THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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