| Identification | Back Directory | [Name]
t-Boc-Aminoxy-PEG4-Tos | [CAS]
1807539-01-0 | [Synonyms]
Boc-Aminoxy-PEG4-Tos
Boc-Aminooxy-PEG4-Tos
t-Boc-Aminoxy-PEG4-Tos
t-Boc-Aminooxy-PEG4-Tos
3,6,9,12-Tetraoxa-2-azatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C20H33NO9S | [MDL Number]
MFCD28064335 | [MOL File]
1807539-01-0.mol | [Molecular Weight]
463.54 |
| Hazard Information | Back Directory | [Description]
t-Boc-Aminooxy-PEG4-Tos is a bifunctional crosslinker reagent with a t-Boc-aminooxy group and a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution. The protected aminooxy can be deprotected under mild acidic conditions. PEG5 spacer increases solubility in aqueous media. | [Uses]
Boc-Aminooxy-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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