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Gilvetmab is a potent caninized anti-PD-1 monoclonal antibody. gilvetmab blocks the interaction between PD-1 and its ligand PDL-1. Gilvetmab can be used in malignant melanoma research[1][2]. | [References]
[1] Magee K, et al. Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting. PLoS One. 2021 Aug 12;16(8):e0255798. DOI:10.1371/journal.pone.0255798
[2] Xia YY, et al. Limited Clinical Efficacy with Potential Adverse Events in a Pilot Study of Autologous Adoptive Cell Therapy in Canine Oral Malignant Melanoma. Vet Sci. 2024 Mar 28;11(4):150. DOI:10.3390/vetsci11040150 |
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