| Identification | Back Directory | [Name]
Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester | [CAS]
180851-50-7 | [Synonyms]
180851-50-7
Tos-O-C4-NH-Boc
Toluene-4-sulfonic acid 4-bocamin
Toluene-4-sulfonic acid 4-bocamino-butyl ester, 97%
Toluene-4-sulfonic acid 4-tert-butoxycarbonylamino-butyl ester
Carbamic acid, N-[4-[[(4-methylphenyl)sulfonyl]oxy]butyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C16H25NO5S | [MDL Number]
MFCD18839142 | [MOL File]
180851-50-7.mol | [Molecular Weight]
343.44 |
| Chemical Properties | Back Directory | [Melting point ]
54-55 °C | [Boiling point ]
491.0±28.0 °C(Predicted) | [density ]
1.151±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.75±0.46(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 [1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21. |
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