| Identification | Back Directory | [Name]
Methanone, [(1S,2R,5S)-2-[[(5-fluoro-2-pyridinyl)oxy]methyl]-8-azabicyclo[3.2.1]oct-8-yl][5-methyl-2-(2-pyrimidinyl)phenyl]- | [CAS]
1808918-69-5 | [Synonyms]
Fazamorexant
Methanone, [(1S,2R,5S)-2-[[(5-fluoro-2-pyridinyl)oxy]methyl]-8-azabicyclo[3.2.1]oct-8-yl][5-methyl-2-(2-pyrimidinyl)phenyl]- | [Molecular Formula]
C25H25FN4O2 | [MOL File]
1808918-69-5.mol | [Molecular Weight]
432.49 |
| Chemical Properties | Back Directory | [Boiling point ]
561.0±50.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.53±0.22(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research[1][2]. | [References]
[1] Zhang Y, et al. Asymmetric Synthesis of Nortropanes via Rh-Catalyzed Allylic Arylation. ACS Catal. 2022 Aug 5;12(15):8995-9002. DOI:10.1021/acscatal.2c02259
[2] Zhenya Zeng, et al. Development of a Scalable Route with Efficient Stereoisomer Control to YZJ-1139, an Orexin Receptor Antagonist. Org. Process Res. Dev. 2022, 26, 2, 447-457. |
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