| Identification | Back Directory | [Name]
Benzeneacetamide, 2,4-dichloro-N-[(3,4-dihydroxyphenyl)methyl]- | [CAS]
1808986-37-9 | [Synonyms]
ERCC1-XPF-IN-2
Benzeneacetamide, 2,4-dichloro-N-[(3,4-dihydroxyphenyl)methyl]- | [Molecular Formula]
C15H13Cl2NO3 | [MOL File]
1808986-37-9.mol | [Molecular Weight]
326.17 |
| Chemical Properties | Back Directory | [Boiling point ]
608.9±55.0 °C(Predicted) | [density ]
1.442±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.58±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays[1]. | [References]
[1] Chapman TM, et al. Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4097-103. DOI:10.1016/j.bmcl.2015.08.031 |
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