| Chemical Properties | Back Directory | [Boiling point ]
781.7±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3?+-.0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
UniPR1331 is a novel selective antagonist of the Eph-ephrin system. | [Uses]
UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish[1]. | [References]
[1] Rusnati M, et al. Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin. Cancer Gene Ther. 2022 Jul;29(7):908-917. DOI:10.1038/s41417-021-00379-5 |
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