| Identification | Back Directory | [Name]
ABBV-4083 | [CAS]
1809266-03-2 | [Synonyms]
ABBV-4083
Compound 5d
ABBV-4083(Compound5d)
Tylosin, 4B-O-[(4-fluorophenyl)methyl]- | [Molecular Formula]
C53H82FNO17 | [MDL Number]
MFCD32062678 | [MOL File]
1809266-03-2.mol | [Molecular Weight]
1024.23 |
| Hazard Information | Back Directory | [Uses]
ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1]. | [in vivo]
ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1]. | Animal Model: | Female BALB/c mice or female jirds were infected at 6–8 weeks of age with L. sigmodontis larvae through the bites of Ornithonyssus bacoti mites[1]. | | Dosage: | 150 mg/kg. | | Administration: | PO once daily for 14 days started at 14 weeks post infection (pti). | | Result: | Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) were reduced
by >99.9% in the recovered female adult worms.
Starting at ~7 weeks pti, levels of circulating microfilariae declined and were completely cleared from 12 weeks pti until the end of this study at 16 weeks pti.
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| [References]
[1] von Geldern TW, et al. Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. DOI:10.1371/journal.pntd.0007159 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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