| Chemical Properties | Back Directory | [Melting point ]
179.7 °C | [Boiling point ]
609.6±55.0 °C(predicted) | [density ]
1.302±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.58±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
Wnt/β-catenin-IN-3 (compound 17) is a Wnt/β-catenin inhibitor with low micromolarGI50s against various cancer cells. Wnt/β-catenin-IN-3triggers G2/M cell cycle arrest though activation of p53-p21 pathway as well as intrinsic and extrinsic apoptotic death of colon cancer cells[1]. | [References]
[1] Hassan AHE, et al. Discovery of a stilbenoid-flavanone hybrid as an antitumor Wnt/β-catenin signaling pathway inhibitor. Bioorg Chem. 2024 Apr;145:107178. DOI:10.1016/j.bioorg.2024.107178 |
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