| Identification | Back Directory | [Name]
(1S,2S,3R)-DT-061 | [CAS]
1809427-20-0 | [Synonyms]
(1S,2S,3R)-DT-061
Benzenesulfonamide, N-[(1S,2S,3R)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)- | [Molecular Formula]
C25H23F3N2O5S | [MOL File]
1809427-20-0.mol | [Molecular Weight]
520.52 |
| Chemical Properties | Back Directory | [Boiling point ]
625.5±65.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (240.14 mM);Methanol : 25 mg/mL (48.03 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
10.48±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis[1]. | [storage]
Store at -20°C | [References]
[1] Kauko O, et al. PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. DOI:10.1126/scitranslmed.aaq1093 |
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MedChemExpress
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