| Identification | Back Directory | [Name]
(R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-N-((R)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide | [CAS]
1809784-29-9 | [Synonyms]
DTP3
DTP3 inhibitor
D-Phenylalaninamide, N-acetyl-D-tyrosyl-D-arginyl-
cancer,DTP 3,inhibit,Inhibitor,Janus kinase,DNA/RNA Synthesis,NF-κB,DTP-3,tumor,GADD45β,DTP3,JAK
(R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-N-((R)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide
(R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-N-((R)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide USP/EP/BP | [Molecular Formula]
C26H35N7O5 | [MDL Number]
MFCD28348368 | [MOL File]
1809784-29-9.mol | [Molecular Weight]
525.6 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [solubility ]
DMSO:100.0(Max Conc. mg/mL);190.26(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);190.26(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);190.26(Max Conc. mM) | [form ]
Solid | [pka]
9.83±0.15(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
1809784-29-9 |
| Hazard Information | Back Directory | [Uses]
DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits the cancer-selective NF-κB survival pathway. It specifically kills cells and induces apoptosis in MM cells without being toxic to normal cells.m | [in vivo]
DTP3 TFA (s.c.; 14.5 mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, and virtually eradicates established subcutaneous myeloma xenografts in mice[2].
DTP3 TFA (intravenous injection; 10 mg/kg/day) has t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg[2].
| Animal Model: | 6 to 8-week old male NOD/SCID mice (NOD.CB17-Prkdcscid/IcrCrl; Charles River)[2] | | Dosage: | 14.5 mg/kg | | Administration: | S.c.; daily; 28 days | | Result: | Had shown a dramatic shrinkage of the tumors. |
| Animal Model: | CD1 male mice of 25-30 g[2] | | Dosage: | 10 mg/kg (Pharmacokinetic Study) | | Administration: | Intravenous injection | | Result: | Had t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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