| Identification | Back Directory | [Name]
Mcl1-IN-9 | [CAS]
1810769-31-3 | [Synonyms]
Mcl1-IN-9
Mcl1 IN 9,Mcl-1-IN-9,Mcl1IN9
Benzoic acid, 3-[[11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4,5-dihydro-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl]methyl]- | [Molecular Formula]
C37H39ClN4O4 | [MDL Number]
MFCD32067984 | [MOL File]
1810769-31-3.mol | [Molecular Weight]
639.18 |
| Chemical Properties | Back Directory | [Boiling point ]
863.0±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
4.19±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1]. | [in vivo]
Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1]. | [IC 50]
Mcl-1: 0.03 nM (Ki) | [References]
[1] Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988. DOI:10.1021/acs.jmedchem.8b01991 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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