| Identification | Back Directory | [Name]
AF40431 | [CAS]
181125-92-8 | [Synonyms]
AF40431
L-Leucine, N-[(7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-yl)methyl]- | [Molecular Formula]
C17H21NO5 | [MDL Number]
MFCD31944050 | [MOL File]
181125-92-8.mol | [Molecular Weight]
319.35 |
| Chemical Properties | Back Directory | [Boiling point ]
549.2±50.0 °C(Predicted) | [density ]
1.261±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA) | [form ]
Solid | [pka]
2.36±0.21(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 μM and a Kd of 0.7 μM . AF40431 is bound in the neurotensin-binding site of sortilin[1]. | [References]
[1] Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60. DOI:10.1107/S1399004713030149 |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|