| Identification | Back Directory | [Name]
Co102862 | [CAS]
181144-66-1 | [Synonyms]
Co102862
V 102862
[(E)-[4-(4-fluorophenoxy)phenyl]methyleneamino]urea
2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide
(E)-2-(4-(4-fluorophenoxy)benz-ylidene)hydrazinecarboxaMide
2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Hydrazinecarboxamide, 2-[[4-(4-fluorophenoxy)phenyl]methylene]- | [Molecular Formula]
C14H12FN3O2 | [MDL Number]
MFCD00953614 | [MOL File]
181144-66-1.mol | [Molecular Weight]
273.26 |
| Chemical Properties | Back Directory | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Powder | [pka]
11.68±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Co 102862 (V 102862) is a potent, broad-spectrum, state-dependent Na+ channel blocker. Co 102862 is also an orally active anticonvulsant[1]. | [Definition]
ChEBI: [[4-(4-fluorophenoxy)phenyl]methylideneamino]urea is an aromatic ether. | [Biological Activity]
Broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na + channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures. | [storage]
Store at RT | [References]
[1] Ilyin VI, et al. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br J Pharmacol. 2005 Mar;144(6):801-12. DOI:10.1038/sj.bjp.0706058 |
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