| Identification | Back Directory | [Name]
CCG215022 | [CAS]
1813527-81-9 | [Synonyms]
CS-2782
CCG215022
CCG215022;CCG-215022;CCG 215022
5-Pyrimidinecarboxamide, 4-[4-fluoro-3-[[(2-pyridinylmethyl)amino]carbonyl]phenyl]-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo- | [Molecular Formula]
C26H22FN7O3 | [MDL Number]
MFCD30489722 | [MOL File]
1813527-81-9.mol | [Molecular Weight]
499.5 |
| Chemical Properties | Back Directory | [Boiling point ]
783.2±60.0 °C(Predicted) | [density ]
1.422±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | [form ]
A crystalline solid | [pka]
11.09±0.70(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Uses]
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, GRK5 and GRK1, respectively. | [References]
[1] Homan KT, et al. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally DesignedInhibitor. J Biol Chem. 2015 Aug 21;290(34):20649-59. DOI:10.1074/jbc.M115.647370 |
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