| Identification | Back Directory | [Name]
Piperazine, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(3-pyridinyl)-, 2,2,2-trifluoroacetate (1:2) | [CAS]
1819366-84-1 | [Synonyms]
cis-22a
Piperazine, 1-[cis-4-(3-methylphenyl)cyclohexyl]-4-(3-pyridinyl)-, 2,2,2-trifluoroacetate (1:2) | [Molecular Formula]
C24H30F3N3O2 | [MOL File]
1819366-84-1.mol | [Molecular Weight]
449.52 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear |
| Hazard Information | Back Directory | [Description]
cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells. | [Uses]
TRPV6-IN-1 is a potent and selective TRPV6 inhibitor. TRPV6-IN-1 has anti-proliferative effect and can be used for the research of cancer[1]. | [IC 50]
TRPV6 | [storage]
Store at -20°C | [References]
[1] Simonin C, et al. Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14748-52. DOI:10.1002/anie.201507320 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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