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NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by 64Cu and 68Ga. 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation[1][2]. NOTA-AE105 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). | [References]
[1] Ris?r LM, et al. Prognostic Value of Urokinase-Type Plasminogen Activator Receptor PET/CT in Head and Neck Squamous Cell Carcinomas and Comparison with 18F-FDG PET/CT: A Single-Center Prospective Study. J Nucl Med. 2022 Aug;63(8):1169-1176. DOI:10.2967/jnumed.121.262866 [2] Persson M, et al. uPAR is a promising new imaging biomarker in glioblastoma[J]. Journal of Nuclear Medicine, 2015. |
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