| Identification | Back Directory | [Name]
GlyT1 Inhibitor 1 | [CAS]
1820934-93-7 | [Synonyms]
GlyT1 Inhibitor 1
GlyT-1 Inhibitor 1,GlyT1 Inhibitor 1
Benzonitrile, 3-[[2,6-dihydro-2-(2-methyl-4-pyridinyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]carbonyl]-4-(1-methylethoxy)- | [Molecular Formula]
C22H21N5O2 | [MDL Number]
MFCD31813671 | [MOL File]
1820934-93-7.mol | [Molecular Weight]
387.43 |
| Chemical Properties | Back Directory | [Boiling point ]
642.3±55.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (64.53 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
4.17±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1]. | [in vivo]
GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1]. | [IC 50]
rGlyT1: 38 nM (IC50) | [References]
[1] Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033. DOI:10.1021/acs.jmedchem.8b00372 |
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