| Identification | Back Directory | [Name]
2-Thiophenebutanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- | [CAS]
1820968-63-5 | [Synonyms]
MSP-3 >=98% (HPLC)
2-Thiophenebutanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]- | [Molecular Formula]
C16H19NO3S | [MDL Number]
MFCD30187586 | [MOL File]
1820968-63-5.mol | [Molecular Weight]
305.39 |
| Chemical Properties | Back Directory | [Boiling point ]
552.3±50.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [form ]
Oil | [pka]
9.76±0.20(Predicted) | [color ]
Colorless to light yellow | [InChI]
1S/C16H19NO3S/c1-20-15-10-12(7-8-14(15)18)11-17-16(19)6-2-4-13-5-3-9-21-13/h3,5,7-10,18H,2,4,6,11H2,1H3,(H,17,19) | [InChIKey]
HCUVEUVIUAJXRB-UHFFFAOYSA-N | [SMILES]
O=C(NCC1=CC=C(O)C(OC)=C1)CCCC2=CC=CS2 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Description]
MSP3 is a transient receptor potential vanilloid type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity. | [Uses]
MSP-3 is a potent TRPV1 agonist, with an EC50 of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects[1]. | [IC 50]
TRPV1: 0.87 μM (EC50) | [References]
[1] Aiello F, et, al. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress. ACS Chem Neurosci. 2016 Jun 15;7(6):737-48. DOI:10.1021/acschemneuro.5b00333 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|