| Identification | Back Directory | [Name]
Methanone, (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-1-piperidinyl]- | [CAS]
1821107-98-5 | [Synonyms]
DNS8254
DNS-8254
DNS 8254
Methanone, (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-1-piperidinyl]- | [Molecular Formula]
C18H15BrF3N5O | [MOL File]
1821107-98-5.mol | [Molecular Weight]
454.24 |
| Hazard Information | Back Directory | [Description]
DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) Inhibitor for the Treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/mimg). In vivo, DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object recognition. DNS-8254 may be a useful tool to explore the pharmacology of selective PDE2a inhibition. | [Uses]
DNS-8254 is an oral active and brain-penetrating PDE2a inhibitor with the IC50 of 8 nM. DNS-8254 shows memory enhancing effects in a rat model[1]. | [References]
[1] Gomez L, et al. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017;60(5):2037-2051. DOI:10.1021/acs.jmedchem.6b01793 |
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