| Identification | Back Directory | [Name]
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester | [CAS]
1821222-10-9 | [Synonyms]
Carbamic acid, N-[4-[[(4-fluorophenyl)methyl]-2-propyn-1-ylamino]-2,6-dimethylphenyl]-, methyl ester | [Molecular Formula]
C20H21FN2O2 | [MOL File]
1821222-10-9.mol | [Molecular Weight]
340.4 |
| Chemical Properties | Back Directory | [Boiling point ]
452.2±45.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (146.89 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.39±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC50 of 37 nM for KCNQ2[1]. HN37 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
HN37 as a potent and chemically stable antiepileptic drug candidate, with an EC50 of 37 nM for KCNQ2[1].
HN37 is a potent neuronal Kv7 activator with a subtype selectivity similar to RTG[1]. | [storage]
Store at -20°C | [References]
[1]. Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64(9):5816-5837. |
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