| Identification | Back Directory | [Name]
ARZOXIFENE HCL | [CAS]
182133-27-3 | [Synonyms]
Serm 3
Ly 353381
Ly 353381 HCl
ARZOXIFENE HCL
Arzoxifene hydrochloride
NHSNLUIMAQQXGR-UHFFFAOYSA-N
2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride | [Molecular Formula]
C28H29NO4S.ClH | [MDL Number]
MFCD00954651 | [MOL File]
182133-27-3.mol | [Molecular Weight]
512.067 |
| Hazard Information | Back Directory | [Uses]
Treatment of symptoms
associated with uterine fibroids, endometriosis, and
dysfunctional uterine bleeding; in the treatment of estrogen
receptor positive recurrent/metastatic breast cancer; as an
adjuvant to breast cancer therapy (selective estrogen
recep. | [in vivo]
Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED50 of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED50 of 0.03 mg/kg/day[2]. |
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