1821647-46-4

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1821647-46-4 Structure

Chemical Properties	Back Directory
[Boiling point ] 716.3±60.0 °C(predicted)
[density ] 1.27±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 4.00±0.10(predicted)

Hazard Information	Back Directory
[Uses] GPR40 agonist 7 (Compound 1) is an orally active G protein-coupled receptor 40 (GPR40) agonist. GPR40 agonist 7 can significantly increase insulin and GLP-1 secretion, and has a hypoglycemic effect in vivo with an ED50 of 0.58 mg/kg[1]
[References] [1] Hou X, et al. Evolution of the Synthetic Process to an Advanced GPR40 Agonist[J]. Organic Process Research & Development, 2024.

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