ChemicalBook--->CAS DataBase List--->1823122-52-6

1823122-52-6

1823122-52-6 Structure

1823122-52-6 Structure
IdentificationBack Directory
[Name]

DOTA-NHS-ester Hexafluorophosphate TFA Salt (Technical Grade)
[CAS]

1823122-52-6
[Synonyms]

DOTA-NHS-ester Hexafluorophosphate TFA Salt
DOTA-NHS-ester Hexafluorophosphate TFA Salt (Technical Grade)
[Molecular Formula]

C22H33F9N5O12P
[MOL File]

1823122-52-6.mol
[Molecular Weight]

761.49
Chemical PropertiesBack Directory
[Melting point ]

176-179°C
[storage temp. ]

Hygroscopic, Refrigerator, under inert atmosphere
[solubility ]

DMSO (Slightly), Methanol (Slightly, Heated)
[form ]

Solid
[color ]

White to Off-White
[Appearance]

white powder
[Stability:]

Hygroscopic
[InChIKey]

NGLVUOKEPPQYJQ-UHFFFAOYSA-O
[SMILES]

C(F)(F)(F)C(=O)O.[P+5]([F-])([F-])([F-])([F-])([F-])[F-].O(N1C(CCC1=O)=O)C(=O)CN1CCN(CCN(CC(=O)O)CCN(CC(=O)O)CC1)CC(=O)O.[H+]
Hazard InformationBack Directory
[Description]

DOTA (dodecane tetraacetic acid, also known as tetraxetan) is a complexing agent, especially for lanthanide ions. DOTA-NHS ester is a bifunctional linker containing chelating and N-hydroxysuccinimide (NHS) ester groups for conjugation with amine-containing biomolecules.


DOTA-NHS ester can be used to label radiotherapeutic agents or imaging probes and detect labeled tumors with PET, SPECT, and CT methods.

[Uses]

DOTA-NHS-ester Hexafluorophosphate TFA Salt is used as a reagent in the preparation of metal or radiometal-labeled-urea- and carbamate-based PSMA inhibitors for PSMA-targeted imaging and radiotherapy.
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