| Identification | Back Directory | [Name]
2-Propynamide, N-[4-(trifluoromethyl)phenyl]- | [CAS]
1823354-06-8 | [Synonyms]
SDH-IN-2
2-Propynamide, N-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C10H6F3NO | [MOL File]
1823354-06-8.mol | [Molecular Weight]
213.16 |
| Hazard Information | Back Directory | [Uses]
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1]. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
SDH-IN-2 (Compound 13) (0-200 μg/mL, 7 days) inhibits the infection of P. piricola on apples[1].
| [References]
[1] Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71(8):3681-3693. DOI:10.1021/acs.jafc.2c07712 |
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