| Identification | Back Directory | [Name]
4-Pyridazinecarbonitrile, 2,3-dihydro-2-(4-methoxyphenyl)-5-methyl-6-[(4-methylphenyl)thio]-3-oxo- | [CAS]
182504-18-3 | [Synonyms]
4-Pyridazinecarbonitrile, 2,3-dihydro-2-(4-methoxyphenyl)-5-methyl-6-[(4-methylphenyl)thio]-3-oxo- | [Molecular Formula]
C20H17N3O2S | [MOL File]
182504-18-3.mol | [Molecular Weight]
363.43 |
| Hazard Information | Back Directory | [Description]
MSD-D is an inhibitor of voltage-gated K(+) (Kv) channels Kv1.5. | [Uses]
MSD-D is a potent and frequency-dependent Kv1.5 channel inhibitor with an IC50 value of 0.5 μM. MSD-D is promising for research of atrial-selective class III antiarrhythmics[2]. | [References]
[1] Strutz-Seebohm N, et al. Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode. Cell Physiol Biochem. 2007;20(6):791-800. DOI:10.1159/000110439 |
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