| Hazard Information | Back Directory | [Description]
LY 302148 is a 5-HT1F receptor agonist that inhibits neurogenic dural inflammation in guinea pigs. LY 302148 has potential for migraine therapeutics. | [Uses]
LY302148 is a receptor ligand for 5-HT1F. Compared to the Emax of 5-HT, LY302148 behaves as a partial agonist for the 5-HT1F receptor. In the [35S]GTPγS binding assay targeting human 5-HT1F receptors, LY302148 exhibits good potency with an EC50 value of 5.23 nM. LY302148 can be used in the research of migraine[1]. | [References]
[1] Wainscott D B, et al. Human 5-HT1F receptor-stimulated [35S] GTPγS binding: correlation with inhibition of guinea pig dural plasma protein extravasation[J]. European journal of pharmacology, 1998, 352(1): 117-124. DOI:10.1016/s0014-2999(98)00336-7 |
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