| Hazard Information | Back Directory | [Description]
LY320954 is a 5-HT2A receptor antagonist. | [Uses]
LY320954 is a selective 5-HT2A receptor antagonist, with a Ki of 96 nM. LY320954 potently inhibits Ca2+ influx in the functional assay (EC50 of 35.5 nM). LY320954 inhibits 5-HT-induced paw swelling in rats, with ED50 of 4.8 mg/kg[1]. | [IC 50]
5-HT2A Receptor: 96 nM (Ki); 5-HT2B Receptor: 1642 nM (Ki); 5-HT2C Receptor: 257 nM (Ki) | [References]
[1] H U Bryant, et al. A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68. DOI:10.1016/0024-3205(96)00449-3 |
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