| Identification | Back Directory | [Name]
DDP-38003 (dihydrochloride) | [CAS]
1831167-98-6 | [Synonyms]
DDP38003
DDP-38003 2HCl
DDP-38003 (dihydrochloride)
DDP 38003 DIHYDROCHLORIDE; DDP38003 DIHYDROCHLORIDE
N-{4-[(1S,2R)-2-Aminocyclopropyl]phenyl}-4-(4-methyl-1-piperazinyl)benzamide dihydrochloride
Benzamide,N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-,hydrochloride(1:2) | [Molecular Formula]
C21H27ClN4O | [MDL Number]
MFCD30718603 | [MOL File]
1831167-98-6.mol | [Molecular Weight]
386.92 |
| Hazard Information | Back Directory | [Description]
DDP-38003 2HCl is an orally available inhibitor of histone lysine-specific demethylase 1A (LSD1). | [Uses]
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM[1]. | [in vivo]
DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1]. | [IC 50]
KDM1/LSD1 | [storage]
Store at -20°C | [References]
[1] Vianello P, et al. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem. 2016 Feb 25;59(4):1501-17. DOI:10.1021/acs.jmedchem.5b01209 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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