| Identification | Back Directory | [Name]
fleephilone | [CAS]
183239-76-1 | [Synonyms]
fleephilone
Butanoic acid, 3-hydroxy-, (2aR,3S,11cR)-2a,4,5,9,10,11c-hexahydro-3-hydroxy-9-methyl-8,10-dioxo-1-(1,3-pentadienyl)-3H,8H-benzo[b]furo[2,3,4-ij]quinolizin-9-yl ester, rel- (9CI) | [Molecular Formula]
C24H27NO7 | [MOL File]
183239-76-1.mol | [Molecular Weight]
441.47 |
| Hazard Information | Back Directory | [Uses]
Fleephilone is a fungal metabolite that can be isolated from Trichoderma harzianum. Fleephilone is a HIV REV/RRE binding inhibitor. Fleephilone inhibits the binding of REV-protein to RRE RNA with an IC50 of 7.6 μM[1]. | [References]
[1] Qian-Cutrone J, et al. Harziphilone and fleephilone, two new HIV REV/RRE binding inhibitors produced by Trichoderma harzianum. J Antibiot (Tokyo). 1996 Oct;49(10):990-7. DOI:10.7164/antibiotics.49.990 |
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