| Identification | Back Directory | [Name]
L-Phenylalanine, N-[(2S)-2-hydroxy-1-oxopropyl]- | [CAS]
183241-73-8 | [Synonyms]
Lac-Phe-OH
N-Lactoyl-Phenylalanine
((S)-2-Hydroxypropanoyl)-L-phe-OH
L-Phenylalanine, N-[(2S)-2-hydroxy-1-oxopropyl]- | [Molecular Formula]
C12H15NO4 | [MOL File]
183241-73-8.mol | [Molecular Weight]
237.25 |
| Chemical Properties | Back Directory | [Melting point ]
>120oC (dec.) | [Boiling point ]
505.1±50.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Sparingly, Sonicated) | [form ]
Solid | [pka]
3.56±0.10(Predicted) | [color ]
White to Off-White | [biological source]
synthetic |
| Hazard Information | Back Directory | [Uses]
N-Lactoyl-Phenylalanine is a useful intermediate in the preparation of chiral morpholinediones by aminolysis of α-hydroxy esters with α-amino acid salts. | [Definition]
ChEBI: N-[(S)-lactoyl]-L-phenylalanine is a L-phenylalanine derivative that is L-phenylalanine in which the amino group is replaced by a [(2S)-2-hydroxypropanoyl]amino group. It is a metabolite produced as a result of exercise in mice, racehorses, and humans which suppresses feeding and obesity. It has a role as a human metabolite, a mouse metabolite, a mammalian metabolite and an anti-obesity agent. It is a L-phenylalanine derivative and a N-acyl-L-amino acid. It is a conjugate acid of a N-[(S)-lactoyl]-L-phenylalaninate. | [in vivo]
N-Lactoyl-Phenylalanine (50 mg/kg, i.p.,once a day for 10 days) specifically suppresses energy intake in obese mice without affecting energy expenditure pathways, and this effect is not observed in lean mice[1]. | Animal Model: | Diet-induced obese (DIO) mice model[1] | | Dosage: | 50 mg/kg | | Administration: | Intraperitoneal (i.p.), once a day for 10 days | | Result: | Resulted in reduced cumulative food intake and reduced body weight compared with control mice. After 10?days, mice treated with N-Lactoyl-Phenylalanine also exhibited improved glucose homeostasis, and reduced adiposity without any changes in the weights of the other organs. |
| [storage]
-20°C |
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