| Identification | Back Directory | [Name]
Erlotinib iMpurity | [CAS]
183321-82-6 | [Synonyms]
Erlotinib impurity, 6,7-bis
Erlotinib iMpurity, 6,7-bis(2-chloroethoxy)
6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine
6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine
4-Quinazolinamine, 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)-
6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine? (Erlotinib Impurity） | [Molecular Formula]
C20H17Cl2N3O2 | [MOL File]
183321-82-6.mol | [Molecular Weight]
402.27 |
| Hazard Information | Back Directory | [Uses]
6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine is an intermediate in the preparation of (bis(morpholinoalkoxy))(phenylamino)quinazolines derivatives as epidermal growth factor receptor (EGFR) inhibitors with anti proliferative activity against tumor cells. | [Synthesis]
Take N'-[2-cyano-4,5-bis(3-chloropropoxy)phenyl]-N,N-dimethylformamidine (1.00mmol), add 2.0mL glacial acetic acid and 4-(E)-aminobenzylpropene (1.10mmol), refluxed at 130 ℃, TLC tracked [Expanding agent: ethyl acetate: petroleum ether (1:2, V/V)] to The |
|
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Roark Standards
|
| Tel: |
0755-83552066 15986688328 |
| Website: |
roarkstandards.com |
|