| Chemical Properties | Back Directory | [Boiling point ]
658.8±55.0 °C(Predicted) | [density ]
1.027±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
An oil | [pka]
5.22±0.33(Predicted) |
| Hazard Information | Back Directory | [Description]
IT-143A is a bacterial metabolite originally isolated from Streptomyces sp. IT-143. It is active against the bacterium M. luteus (MIC = 6.25 μg/ml) and the fungi A. fumigatus and T. rubrum in vitro (MICs = 12.5-25 μg/ml). | [Uses]
IT-143A is an antibiotic, that exhibits antibacterial and antifungal activity against Micrococcus luteus and Aspergillus fumigatus with MIC of 6.25-25 μg/mL. IT-143A inhibits growth of cancer cell KB with an IC50 of 0.36 ng/mL[1]. | [References]
[1] Urakawa A, et al., IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp. J Antibiot (Tokyo). 1996 Oct;49(10):1052-5. DOI:10.7164/antibiotics.49.1052 |
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