| Identification | Back Directory | [Name]
4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE | [CAS]
183500-36-9 | [Synonyms]
4-(5-HYDROXYMETHYLIMIDAZOL-1-YLMETHYL)BENZONITRILE | [Molecular Formula]
C12H11N3O | [MDL Number]
MFCD08668150 | [MOL File]
183500-36-9.mol | [Molecular Weight]
213.235 |
| Hazard Information | Back Directory | [Uses]
CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and
aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer[1]. | [References]
[1] Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23. DOI:10.1021/acsptsci.3c00183 |
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Greenchem Institute
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