| Identification | Back Directory | [Name]
Pan-RAS-IN-1 | [CAS]
1835283-94-7 | [Synonyms]
Ras-IN-3144
Pan-RAS-IN-1
Pan-RAS inhibitor 1
pan-Ras inhibitor 3144
Ras-IN-3144，Pan-RAS-IN-1
pan-Ras inhibitor 3144 (Compound 3144)
PanRASIN1,inhibit,Ras,Pan RAS IN 1,Inhibitor
4-Piperidinecarboxamide, 4-amino-N-[3-[5-[[4-[(2,6-dichlorophenyl)methyl]-1-piperazinyl]methyl]-3-[4-(trifluoromethoxy)phenyl]-1H-indol-1-yl]propyl]- | [Molecular Formula]
C36H41Cl2F3N6O2 | [MDL Number]
MFCD31382126 | [MOL File]
1835283-94-7.mol | [Molecular Weight]
717.65 |
| Chemical Properties | Back Directory | [Boiling point ]
809.7±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 50 mg/mL (69.67 mM) | [form ]
Solid | [pka]
17.09±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors. | [in vivo]
Pan-RAS-IN-1 administration results in inhibition of tumor growth over 15 days of treatment. Pan-RAS-IN-1-treated mice exhibits decreased tumor pERK levels compared with vehicle treated mice. A modest increase in cleaved caspase-3 is also observed, showing that in this model, pan-RAS-IN-1 has the capacity to induce caspase activation[1]. | [References]
[1] Welsch ME, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017 Feb 23;168(5):878-889.e29. DOI:10.1016/j.cell.2017.02.006 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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