| Hazard Information | Back Directory | [Description]
YZ51 is a novel potent inhibitor of ribonucleotide reductase (RR), inhibiting hepatitis B virus replication by targeting ribonucleotide reductase M2 protein. | [Uses]
YZ51 is a derivative of Osalmid (HY-B2116) with stronger ribonucleotide reductase (RR) inhibitory activity and HBV replication inhibition ability than Osalmid. The IC50 of YZ51 against recombinant RR activity is 0.6 μM, and the IC50 against HepG2.2.15 cell RR activity is 23.7 μM[1]. | [References]
[1] Xia Liu, et al. "Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein." Biochemical Pharmacology 103 (2016): 118-128. DOI:10.1016/j.bcp.2016.01.003 |
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