| Identification | Back Directory | [Name]
Glycinamide, 3-cyclohexyl-N-(5-isoxazolylcarbonyl)-L-alanyl-2-cyclohexyl-, (2S)- | [CAS]
1835734-92-3 | [Synonyms]
Glycinamide, 3-cyclohexyl-N-(5-isoxazolylcarbonyl)-L-alanyl-2-cyclohexyl-, (2S)- | [Molecular Formula]
C21H32N4O4 | [MOL File]
1835734-92-3.mol | [Molecular Weight]
404.5 |
| Chemical Properties | Back Directory | [Boiling point ]
740.2±50.0 °C(Predicted) | [density ]
1.183±0.06 g/cm3(Predicted) | [solubility ]
Soluble to 1 mg/ml in ethanol | [pka]
12.09±0.46(Predicted) | [Sequence]
{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2 |
| Hazard Information | Back Directory | [Description]
AY77 is a Potent protease activated receptor 2 (PAR2) calcium-biased agonist (EC50 40 nM, Ca2+; EC50 2 μM, ERK1/2). | [Uses]
AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2]. | [IC 50]
PAR2 | [storage]
Store at -20°C | [References]
[1] Kl?sel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323. DOI:10.1021/acsmedchemlett.0c00154
[2] Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. DOI:10.1021/acschembio.6b01088 |
|
|