| Identification | Back Directory | [Name]
N-(3-hydroxyphenyl)-Arachidonoyl amide | [CAS]
183718-75-4 | [Synonyms]
N-(3-hydroxyphenyl)-Arachidonoyl amide
N-(3-hydroxyphenyl)-Arachidonoyl amide Exclusive
5,8,11,14-Eicosatetraenamide, N-(3-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C26H37NO2 | [MDL Number]
MFCD12912675 | [MOL File]
183718-75-4.mol | [Molecular Weight]
395.58 |
| Chemical Properties | Back Directory | [Boiling point ]
579.4±50.0 °C(Predicted) | [density ]
1.007±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤20mg/ml in DMSO;20mg/ml in dimethyl formamide | [form ]
solution in ethanol. | [pka]
9.57±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(3-hydroxyphenyl)-Arachidonoyl amide (3-HPA) is an analog of AM404 (N-(4-hydroxyphenyl)-arachidonoyl amide), which is a selective inhibitor of carrier-mediated transport of arachidonoyl ethanolamide (AEA). 3-HPA is metabolized by both cyclooxygenase-1 (COX-1) and COX-2 and was found to selectively and irreversibly inhibit COX-2 with an IC50 value of 2 μM. | [Uses]
N-(3-hydroxyphenyl)-Arachidonoyl amide is a selective, irreversible inhibitor of COX-2. | [Definition]
ChEBI: N-(3-hydroxyphenyl)-Arachidonoyl amide is an anilide. | [IC 50]
2 μm | [References]
[1]. fitzpatrick, f. cyclooxygenase enzymes: regulation and function. current pharmaceutical design. 2004; 10(6): 577-588. |
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