| Identification | Back Directory | [Name]
9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE | [CAS]
183721-15-5 | [Synonyms]
MRS 1220
MRS 1220 solid
9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA
9-chloro-2-(2-furanyl)-5-((phenylacetyl)amino)-[1,2,4]triazolo[1,5-c]quinazoline
9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE
N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE
Benzeneacetamide, N-[9-chloro-2-(2-furanyl)[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-
MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINA
MRS 1220;9-CHLORO-2-(2-FURANYL)-5-[(PHENYLACETY)AMINO][1,2,4]-TRIAZOLO[1,5-C] QUINAZOLINE;N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE;MRS 1220;9-CHLORO-2-(2-FURANYL)-5-((PHENYLACETYL)AMINO)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE | [Molecular Formula]
C21H14ClN5O2 | [MDL Number]
MFCD01321046 | [MOL File]
183721-15-5.mol | [Molecular Weight]
403.82 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: 2 mg/mL | [form ]
solid | [pka]
8.17±0.46(Predicted) | [color ]
white | [InChI]
1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28) | [InChIKey]
TWWFAXQOKNBUCR-UHFFFAOYSA-N | [SMILES]
Clc1ccc2nc(NC(=O)Cc3ccccc3)n4nc(nc4c2c1)-c5ccco5 |
| Hazard Information | Back Directory | [Uses]
MRS 1220 is a highly potent and selective human Adenosine A3-R antagonist. | [Definition]
ChEBI: N-[9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-2-phenylacetamide is a member of quinazolines. | [Biological Activity]
A potent and highly selective antagonist at the human A 3 adenosine receptor (K i values are 0.65, 305, and 52 nM at hA 3 , rA 1 and rA 2A respectively. Displays an IC 50 value > 1 μ M for inhibition of binding to rat A 3 receptors). | [in vivo]
MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2]. | Animal Model: | Eight, 8 week-old male Sprague-Dawley rats bearing C6 (GSCs)[2] | | Dosage: | 0.15 mg/kg/72 h | | Administration: | Administered by intraperitoneal inoculation, for fifteen days | | Result: | A reduction close to 80% and 90% in tumor volume compared to the vehicle-treated group at day ten and fifteen post-treatment, respectively.
|
| [storage]
Store at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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